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Toxic fungi may hold secrets to tackling deadly diseases

A team of scientists has discovered an enzyme that is the key to the lethal potency of poisonous mushrooms. The results reveal the enzyme’s ability to create the mushroom’s molecules that harbor missile like proficiency in attacking and annihilating a single vulnerable target in the human liver. The team revealed how the enzyme contributes to the manufacture of chemical compounds known as cyclic peptides, a favorite type of molecule that pharmaceutical companies use to create new drugs. Mushrooms are prolific chemical factories, yet only a few of their peptides are poisonous. These toxins survive the high temperatures of cooking and the acids of digestion, and yet they’re readily absorbed by the bloodstream and go directly to their intended target. These are the exact qualities needed for an effective medicine. The enzyme the team discovered is called POPB, and it converts toxins from their initial linear shape into cyclic peptides, fortress like molecular circles comprising eight amino acids.

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