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In pedigree chart analysis how to determine whether it is autosomal (dominant and recessive) or x linked (dominant and recessive)?
Home » Queries & Discussions » In pedigree chart analysis how to determine whether it is autosomal (dominant and recessive) or x linked (dominant and recessive)?
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a.) If most of the males in the pedigree are affected, then the disorder is X-linked. If it is a 50/50 ratio between men and women the disorder is autosomal.
b.) If the disorder is dominant, one of the parents must have the disorder. If the disorder is recessive, neither parent has to have the disorder because they can be heterozygous.
1. Autosomal Recessive
Appears in both sexes with equal frequency
Trait tend to skip generations
Affected offspring are usually born to unaffected parents
When both parents are hetrozygous, approx. 1/4 of the progeny will be affected
Appears more frequently among the children of consanguine marriages.
2. Autosomal Dominant
Appears in both sexes with equal frequency
Both sexes transmit the trait to their offspring
Does not skip generations
Affected offspring must have an affected parent unless they posses a new mutation
When one parent is affected (het.) and the other parent is unaffected, approx. 1/2 of the offspring will be affected
Unaffected parents do not transmit the trait
3. X-Linked Dominant
Both males and females are affected; often more females than males are affected
Does not skip generations.
Affected sons must have an affected mother;
Affected daughters must have either an affected mother or an affected father
Affected fathers will pass the trait on to all their daughters
Affected mothers if heterozygous will pass the trait on to 1/2 of their sons and 1/2 of their daughters
4. X-Linked Recessive
More males than females are affected
Affected sons are usually born to unaffected mothers, thus the trait skips generations Approximately 1/2 of carrier mothers’ sons are affected
It is never passed from father to son
All daughters of affected fathers are carriers