Nano-cocoons designed to deliver drugs effectively against cancer cells

Biomedical engineering researchers have developed a drug delivery system consisting of nanoscale “cocoons” made of DNA that target cancer cells and trick the cells into absorbing the cocoon before unleashing anticancer drugs. The work was done by researchers at North Carolina State University and the University of North Carolina at Chapel Hill. This drug delivery system is DNA-based, which means it is biocompatible and less toxic to patients than systems that use synthetic materials. This technique specifically targets cancer cells and carry a large drug load and releases the drugs very quickly once inside the cancer cell.It is relatively easy to manufacture. Each nano-cocoon is made of a single strand of DNA that self-assembles into what looks like a cocoon, or ball of yarn. The core of the nano-cocoon contains the anticancer drug doxorubicin (DOX) and a protein called DNase. The DNase, an enzyme that would normally cut up the DNA cocoon, is coated in a thin polymer that traps the DNase like a sword in a sheath. The surface of the nano-cocoon is studded with folic acid ligands. When the nano-cocoon encounters a cancer cell, the ligands bind the nano-cocoon to receptors on the surface of the cell making the cell to suck in the nano-cocoon. Once it is inside the cancer cell, the cell’s acidic environment destroys the polymer sheath containing the DNase. Freed from its sheath, the DNase rapidly slices through the DNA cocoon, spilling DOX into the cancer cell and killing it.