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In pedigree chart analysis how to determine whether it is autosomal (dominant and recessive) or x linked (dominant and recessive)?

By Derojeo Choudhary

In pedigree chart analysis how to determine whether it is autosomal (dominant and recessive) or x linked (dominant and recessive)?

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One comment

  1. a.) If most of the males in the pedigree are affected, then the disorder is X-linked. If it is a 50/50 ratio between men and women the disorder is autosomal.

    b.) If the disorder is dominant, one of the parents must have the disorder. If the disorder is recessive, neither parent has to have the disorder because they can be heterozygous.

    1. Autosomal Recessive

    Appears in both sexes with equal frequency
    Trait tend to skip generations
    Affected offspring are usually born to unaffected parents
    When both parents are hetrozygous, approx. 1/4 of the progeny will be affected
    Appears more frequently among the children of consanguine marriages.

    2. Autosomal Dominant

    Appears in both sexes with equal frequency

    Both sexes transmit the trait to their offspring

    Does not skip generations

    Affected offspring must have an affected parent unless they posses a new mutation

    When one parent is affected (het.) and the other parent is unaffected, approx. 1/2 of the offspring will be affected

    Unaffected parents do not transmit the trait

    3. X-Linked Dominant

    Both males and females are affected; often more females than males are affected
    Does not skip generations.

    Affected sons must have an affected mother;

    Affected daughters must have either an affected mother or an affected father

    Affected fathers will pass the trait on to all their daughters

    Affected mothers if heterozygous will pass the trait on to 1/2 of their sons and 1/2 of their daughters

    4. X-Linked Recessive

    More males than females are affected

    Affected sons are usually born to unaffected mothers, thus the trait skips generations Approximately 1/2 of carrier mothers’ sons are affected

    It is never passed from father to son

    All daughters of affected fathers are carriers

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